Cell identity & gene expression

Single-nucleus RNA sequencing

See the biology hidden inside your sample. We isolate nuclei from frozen tissue, generate single-nucleus RNA libraries, and tailor sequencing and analysis to your study.

Service workflow diagram
A clearer view of your biology

The questions
you can explore.

Single-nucleus RNA sequencing reveals how gene expression varies across cell populations while avoiding the need to recover intact protoplasts from difficult tissues.

  1. 01Which cell populations are present in my tissue?
  2. 02How does gene expression differ between conditions?
  3. 03Which genes help explain a cell type’s identity or response?
Your project outputs

Define what you need
for your next step.

Agreed project scope can include the following. Deliverables and analysis depth are specified during project design.

01

Libraries & quality checks

Sequencing-ready libraries with preparation and library quality information for the agreed workflow.

02

Expression matrices

Processed gene-by-nucleus data alongside sequencing quality summaries when analysis is included.

03

Clustering & markers

Cell-population clustering, marker genes, and preliminary annotation appropriate to the available references.

04

Tailored analysis

Project-specific comparisons, integration, trajectory analysis, or other advanced work when scientifically appropriate.

Bring us your sample and question.

We’ll help define the appropriate assay, controls, sequencing, and analysis scope.

Discuss this service