Binding-site maps
Genome-wide candidate binding regions for the transcription factor under the agreed workflow.
Connect a transcription factor to the genomic DNA sequences it can bind in vitro. DAP-seq can identify binding sites and sequence preferences to prioritize regulatory hypotheses.
DAP-seq is an in-vitro DNA-affinity assay. It identifies binding potential and does not by itself establish binding or regulation inside a living cell.
Agreed project scope can include the following. Deliverables and analysis depth are specified during project design.
Genome-wide candidate binding regions for the transcription factor under the agreed workflow.
Sequence motifs enriched among candidate binding sites.
Nearby genes or regulatory features that can be prioritized for follow-up.
Comparison among transcription factors, alleles, or sequence contexts when supported by the study design.
We’ll help define the appropriate assay, controls, sequencing, and analysis scope.