Single-nucleus RNA
Single-nucleus RNA sequencing
Resolve gene expression across individual nuclei. Reveal cellular diversity and explore how populations respond to development, treatment, or the environment.
Explore RNA sequencingSINGLE-NUCLEUS RNA-SEQ, CUT& TAG and DAP-SEQ
Single-cell
genomics.Built for
your biology.
From challenging tissues to interpretable data, we help researchers explore gene expression and regulation across plants, animals, and fungi.
30+ speciesSingle-nucleus RNA-seq experience
PlantsMaize · Soybean · Strawberry ground-cherry
AnimalsSalmon · Spiny mouse · House mouse
FungiGray inkcap mushroom
Three services. Complementary perspectives.
Start with your
scientific question.
Explore cellular identity, chromatin profiles, and transcription-factor binding—with the right approach for each measurement.
Bulk chromatin profiling
CUT&Tag
Map selected histone marks across your sample. Compare chromatin profiles between conditions and connect the results with gene expression and candidate regulatory regions.
Explore CUT&Tag
Transcription-factor binding
DAP-seq
Map genomic DNA sequences a transcription factor can bind. Identify binding sites and sequence motifs to prioritize regulatory hypotheses and candidate target genes.
Explore DAP-seqNot sure which approach fits your project? Let’s work through it together.
The SolusCell approach
Some samples need more
than a standard protocol.
Your species, your tissue, your biological question. We start there to develop the experimental approach and analysis strategy your project needs.
Explore our RNA-seq experience- 01
Experience with challenging tissues
Sample-specific nuclei isolation and preparation, with feasibility and quality considered from the start.
- 02
A scope that fits your team
From library preparation to sequencing and analysis, choose the support that complements your expertise.
- 03
Biology in context
Connect your outputs to the questions, references, and experimental comparisons that matter to your research.
RNA sequencing projects
The right scale
for your research.
From a focused feasibility study to a coordinated research program, we shape single-nucleus RNA sequencing around your samples, study design, and scientific goals.
Feasibility
Start small. Define the next step.For pilot projects, new species or tissues, and focused exploratory studies. Assess sample preparation and initial RNA data to guide what comes next.
- Sample preparation and workflow assessment
- RNA library preparation, initial sequencing, and quality checks
- A feasibility report with recommended next steps
Standard
Compare conditions. Explore the biology.For studies spanning conditions, genotypes, treatments, or time points, with biological replicates and an analysis plan built around your question.
- RNA libraries, sequencing, and quality control
- Expression matrices, clustering, and marker genes
- A study report and agreed comparisons between conditions
Research Programs
A coordinated plan for larger studies.For industry teams and research groups planning a large individual study or an ongoing research program.
- Experimental planning and coordinated sample processing
- Tailored sequencing, analysis, and reporting
- Agreed milestones and scientific support
These options describe single-nucleus RNA sequencing projects. CUT&Tag and DAP-seq are scoped separately around the samples, controls, and analysis required.
How we work
From your question
to your next discovery.
A clear processing path with quality checks at each stage.
→
Nuclei QC
Nuclei Isolation
→
Library QC
Single-Nucleus
Library Preparation
Library Preparation
→
Data QC
Sequencing
Illumina NovaSeq X
>200M PE150 reads
>200M PE150 reads
→
Bioinformatics
Analysis
View Sample Report ↗
Analysis
Let’s build your next experiment.
Tell us about your species, tissue, samples, and biological question.